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This suggests a less integrated interictal whole-brain network. The overall group difference, quantified as the standardized mean average path length difference between epilepsy and control groups, corresponded to a significantly increased average path length of 0.29 (95% confidence interval (CI): 0.12 to 0.45, pā=ā0.0007) in the epilepsy group. Twelve studies were included that reported whole-brain network average path length and average clustering coefficient characteristics in patients and controls. We focused on the two most commonly used metrics in whole-brain networks: average path length and average clustering coefficient.
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We therefore systematically reviewed the existing literature and conducted a meta-analysis to characterize the changes in whole-brain interictal focal epilepsy networks at sufficient power levels. Nevertheless, the reported network alterations are inconclusive and prone to low statistical power due to small sample sizes as well as modest effect sizes. Increasing evidence exists that interictal network alterations in focal epilepsy are associated with cognitive and behavioral deficits.
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Normal brain functioning is presumed to depend upon interacting regions within large-scale neuronal networks.